Cornelia Africana Major (b. circa 201 BCE, d. unknown) was the first daughter of Aemilia Tertia and Scipio Africanus.
Scipio Nasica Corculum was her husband and second cousin. She had a single child. Judging by the year her son, Scipio Nasica Serapio, became consul in 138 BCE she probably married around 184-183 BCE.
Cornelia Africana Major had three siblings. They were Publius Cornelius P.f. P.n. Scipio Africanus (fl. 174 BC), Lucius Cornelius P.f. P.n. Scipio (fl. 174 BC), and Cornelia Africana Minor (c.192-121 BC).